Structural highlights
Publication Abstract from PubMed
Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-A) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in binding ATP and RNA. We identify druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery.
Structure of the NS3 helicase from Zika virus.,Jain R, Coloma J, Garcia-Sastre A, Aggarwal AK Nat Struct Mol Biol. 2016 Aug;23(8):752-4. doi: 10.1038/nsmb.3258. Epub 2016 Jul , 11. PMID:27399257[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Jain R, Coloma J, Garcia-Sastre A, Aggarwal AK. Structure of the NS3 helicase from Zika virus. Nat Struct Mol Biol. 2016 Aug;23(8):752-4. doi: 10.1038/nsmb.3258. Epub 2016 Jul , 11. PMID:27399257 doi:http://dx.doi.org/10.1038/nsmb.3258
