1bii
From Proteopedia
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THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110
Overview
The structure of H-2Dd complexed with the HIV-derived peptide P18-I10, (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A, resolution. This MHC class I molecule has an unusual binding motif with, four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10)., The cleft architecture of H-2Dd includes a deep narrow passage, accomodating the N-terminal part of the peptide, explaining the obligatory, G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V, form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional, data available for T cell and natural killer cell recognition of the H-2Dd, molecule.
About this Structure
1BII is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition., Achour A, Persson K, Harris RA, Sundback J, Sentman CL, Lindqvist Y, Schneider G, Karre K, Immunity. 1998 Aug;9(2):199-208. PMID:9729040
Page seeded by OCA on Thu Nov 8 13:53:40 2007
