2uui

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spinqualitylabelsall models 2uui, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF HUMAN LEUKOTRIENE C4 SYNTHASE

Overview

Cysteinyl leukotrienes are key mediators in inflammation and have an, important role in acute and chronic inflammatory diseases of the, cardiovascular and respiratory systems, in particular bronchial asthma. In, the biosynthesis of cysteinyl leukotrienes, conversion of arachidonic acid, forms the unstable epoxide leukotriene A4 (LTA4). This intermediate is, conjugated with glutathione (GSH) to produce leukotriene C4 (LTC4) in a, reaction catalysed by LTC4 synthase: this reaction is the key step in, cysteinyl leukotriene formation. Here we present the crystal structure of, the human LTC4 synthase in its apo and GSH-complexed forms to 2.00 and, 2.15 A resolution, respectively. The structure reveals a homotrimer, where, each monomer is composed of four transmembrane segments. The structure ... [(full description)]

About this Structure

2UUI is a [Single protein] structure of sequence from [Homo sapiens] with NI, SO4, LMT and PLM as [ligands]. Active as [[1]], with EC number [4.4.1.20]. Full crystallographic information is available from [OCA].

Reference

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase., Molina DM, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P, Nature. 2007 Aug 2;448(7153):613-6. Epub 2007 Jul 15. PMID:17632546

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