NudT16

From Proteopedia

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Contents 1 Introduction 2 Structure 3 Function 4 Disease 5 Relevance 6 Structural highlights 7 References

Introduction

NudT16 is a hydrolase and belongs to the nucleoside diphosphate-linked moiety X (Nudix) family. This protein regulates levels of 53BP1 which is a protein that recruits other proteins to the site of a DNA breakage. NudT16 has also shown in vitro to remove ADP-ribosylation through its hydrolase activities.

Structure

NudT16 is a dimer

spinqualitylabelsall models Crystal structure of HsNUDT16 in complex with diADPR (soaked) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models 5VY2 F36A mutant Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models 5JWI Crystal structure of Porphyromonas endodontalis DPP11 in complex with dipeptide Arg-Glu Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Function

Disease

Relevance

Structural highlights

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References