1k5m

From Proteopedia

Crystal Structure of a Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 V3 Loop Chimeric Virus MN-III-2

Overview

We report the 2.7 A resolution structure of a chimeric rhinovirus, MN-III-2, that displays part of the HIV-1 gp120 V3 loop and elicits, HIV-neutralizing antibodies. The V3 loop insert is dominated by two type I, beta turns. The structures of two adjacent tripeptides resemble those of, analogous segments in three Fab/V3 loop peptide complexes. Although two of, the three corresponding antibodies bind and neutralize MN-III-2 well, only, one of the three can bind without significant rearrangement. These results, suggest that the V3 loop insert: (1) can share some local conformational, similarity to V3 loop sequences presented on different structural, frameworks; (2) must be able to adopt multiple conformations, even in a, relatively constrained environment; and (3) may mimic the conformational, variability of the epitope on HIV-1, increasing the likelihood of, eliciting appropriate neutralizing immune responses.

About this Structure

1K5M is a Protein complex structure of sequences from Human rhinovirus 10 with SPH as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1., Ding J, Smith AD, Geisler SC, Ma X, Arnold GF, Arnold E, Structure. 2002 Jul;10(7):999-1011. PMID:12121655

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