1nak

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Image:1nak.gif

1nak, resolution 2.57Å

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IGG1 FAB FRAGMENT (83.1) COMPLEX WITH 16-RESIDUE PEPTIDE (RESIDUES 304-321 OF HIV-1 GP120 (MN ISOLATE))

Overview

The crystal structure of the human immunodeficiency virus type 1 (HIV-1), neutralizing, murine Fab 83.1 in complex with an HIV-1 gp120 V3 peptide, has been determined to 2.57 A resolution. The conformation of the V3 loop, peptide in complex with Fab 83.1 is very similar to V3 conformations seen, previously with two other neutralizing Fabs, 50.1 and 59.1. The repeated, identification of this same V3 conformation in complex with three very, different, neutralizing antibodies indicates that it is a highly preferred, structure for V3 loops on some strains of the HIV-1 virus.

About this Structure

1NAK is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop., Stanfield RL, Ghiara JB, Ollmann Saphire E, Profy AT, Wilson IA, Virology. 2003 Oct 10;315(1):159-73. PMID:14592768

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