This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1qmc
From Proteopedia
|
C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES
Overview
The structure of the C-terminal DNA-binding domain of human immunovirus-1, integrase has been refined using nuclear magnetic resonance spectroscopy., The protein is a dimer in solution and shows a well-defined dimer, interface. The folding topology of the monomer consists of a five-stranded, beta-barrel that resembles that of Src homology 3 domains. Compared with, our previously reported structure, the structure is now defined far, better. The final 42 structures display a back-bone root mean square, deviation versus the average of 0.46 A. Correlation of the structure with, recent mutagenesis studies suggests two possible models for DNA binding., Proteins 1999;36:556-564.
About this Structure
1QMC is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase., Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R, Proteins. 1999 Sep 1;36(4):556-64. PMID:10450096
Page seeded by OCA on Thu Nov 8 14:24:37 2007
