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Fascin

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Human fascin complex with anti-metastatic inhibitor (PDB id 6i0z).

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3D structures of fascin

1dfc, 3llp, 3p53 - hFASC 1 - human
4gov, 4goy, 4gp0, 4gp3 - hFASC 1 (mutant)
6i0z, 6i17, 6i16, 6i18, 6i11, 6i10, 6i13, 6i12, 6i15, 6i14 - hFASC + anti-metastatic inhibitor
6b0t - hFASC + inhibitor

References

  1. Gungor-Ordueri NE, Cheng CY. Fascin - An actin binding and bundling protein in the testis and its role in ectoplasmic specialization dynamics. Spermatogenesis. 2015 Feb 23;5(1):e1002733. doi: 10.1080/21565562.2014.1002733., eCollection 2015 Jan-Apr. PMID:26413410 doi:http://dx.doi.org/10.1080/21565562.2014.1002733
  2. Al-Alwan M, Olabi S, Ghebeh H, Barhoush E, Tulbah A, Al-Tweigeri T, Ajarim D, Adra C. Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules. PLoS One. 2011;6(11):e27339. doi: 10.1371/journal.pone.0027339. Epub 2011 Nov 4. PMID:22076152 doi:http://dx.doi.org/10.1371/journal.pone.0027339
  3. Qualtrough D, Smallwood K, Littlejohns D, Pignatelli M. The actin-bundling protein fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair. BMC Gastroenterol. 2011 Feb 23;11:14. doi: 10.1186/1471-230X-11-14. PMID:21345224 doi:http://dx.doi.org/10.1186/1471-230X-11-14

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