Cystathionine gamma synthase

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Tobacco cystathionine gamma synthatase complex with inhibitor (PDB code 1i41)

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3D structures of cystathionine gamma synthase

1i41 - tCGS + inhibitor - tobacco
1qgn - tCGS + PLP
1i43, 1i48 - tCGS + PLP + inhibitor
1cs1 - CGS + PLP derivative - Eschericia coli
4l0o - CGS + PLP - Helicobacter pylori
6s0c - CGS + PLP - Citrobacter freundii
3qi6, 3qhx - CGS MetB - Mycobacterium ulcerans
5x5h - CGS MetB - Corynebacterium glutamicum

References

  1. ↑ Flavin M, Slaughter C. Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine. Biochim Biophys Acta. 1967 Mar 15;132(2):400-5. doi:, 10.1016/0005-2744(67)90158-1. PMID:5340123 doi:http://dx.doi.org/10.1016/0005-2744(67)90158-1
  2. ↑ Fu J, Wu J, Jiang J, Wang Z, Ma Z. Cystathionine gamma-synthase is essential for methionine biosynthesis in Fusarium graminearum. Fungal Biol. 2013 Jan;117(1):13-21. doi: 10.1016/j.funbio.2012.11.001. Epub 2012 , Dec 1. PMID:23332829 doi:http://dx.doi.org/10.1016/j.funbio.2012.11.001
  3. ↑ Steegborn C, Laber B, Messerschmidt A, Huber R, Clausen T. Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J Mol Biol. 2001 Aug 24;311(4):789-801. PMID:11518531 doi:10.1006/jmbi.2001.4880

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