Function
Galactokinase (GALK) is the enzyme which catalyzes the second step in the Leloir pathway which converts β-D-galactose to glucose 1-phosphate. GALK catalyzes the conversion of α-D-galactose to galactose 1-phosphate[1].
Disease
Hereditary GALK deficiency is called galactosemia. The symptoms are early onset of cataract and impairment of galactose (gal) metabolism[2]..
Structural highlights
3D structures of galactokinase
6gr2 - hGK + ADP + gal - human
1wuu - hGK + Mg + AMPPNP + gal
6q3w, 6q8z - hGK + pyrazine derivative + gal
6q91 - hGK + benzamide derivative + gal
6q90, 6zgw - hGK + pyridine derivative + gal
6q3x - hGK + quinazoline derivative + gal
6zgv, 6zgx, 6zgz, 6zgy - hGK + pyrimidine derivative + gal
6qje - hGK + imidazole derivative + gal
2aj4 - GK + Mg + AMPPNP + gal - yeast
1s4e - GK + Mg + ADP + gal - Pyrococcus furiosus
2dej, 2dei - GK + AMPPN derivative + gal - Pyrococcus horikoshii
1pie - GK + gal - Lactococcus lactis
6tep - BiGK + Mg + ADP - Bifidobacterium infantis
6ter, 6teq - BiGK + gal derivative