1vru
From Proteopedia
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HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Overview
We have determined the structures of four complexes of HIV-1 reverse, transcriptase with non-nucleoside inhibitors, three fully refined at high, resolution. The highest resolution structure is of the RT-nevirapine, complex which has an R-factor of 0.186 and a root-mean-square bond length, deviation of 0.015 A for all data to 2.2 A. The structures reveal a common, mode of binding for these chemically diverse compounds. The common, features of binding are largely hydrophobic interactions and arise from, induced shape complementarity achieved by conformational rearrangement of, the enzyme and conformational/configurational rearrangement of the, compounds.
About this Structure
1VRU is a Protein complex structure of sequences from Human immunodeficiency virus 1 with CYA and AAP as ligands. Active as RNA-directed DNA polymerase, with EC number 2.7.7.49 Full crystallographic information is available from OCA.
Reference
High resolution structures of HIV-1 RT from four RT-inhibitor complexes., Ren J, Esnouf R, Garman E, Somers D, Ross C, Kirby I, Keeling J, Darby G, Jones Y, Stuart D, et al., Nat Struct Biol. 1995 Apr;2(4):293-302. PMID:7540934
Page seeded by OCA on Thu Nov 8 14:34:21 2007
