This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2bpv
From Proteopedia
|
HIV-1 PROTEASE-INHIBITOR COMPLEX
Overview
The ability to replace an inhibitor bound to the HIV-1 protease in single, crystals with other potent inhibitors offers the possibility of, investigating a series of protease inhibitors rapidly and conveniently, with the use of X-ray crystallography. This approach affords a fast, turnaround of structural information for iterative rational drug designs, and obviates the need for studying the complex structures by, co-crystallization. The replacement approach has been successfully used, with single crystals of the HIV-1 protease complexed with a weak, inhibitor. The structures of the complexes obtained by the replacement, method are similar to those determined by co-crystallization.
About this Structure
2BPV is a Single protein structure of sequence from Human immunodeficiency virus 1 with 1IN as ligand. Active as Deleted entry, with EC number 3.4.13.16 Full crystallographic information is available from OCA.
Reference
Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme., Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. PMID:9757136
Page seeded by OCA on Thu Nov 8 14:44:09 2007
