Structural highlights
Function
[SRF_HUMAN] SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.
Structure of serum response factor core bound to DNA.,Pellegrini L, Tan S, Richmond TJ Nature. 1995 Aug 10;376(6540):490-8. PMID:7637780[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Pellegrini L, Tan S, Richmond TJ. Structure of serum response factor core bound to DNA. Nature. 1995 Aug 10;376(6540):490-8. PMID:7637780 doi:http://dx.doi.org/10.1038/376490a0
