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1ddj

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Revision as of 10:43, 2 May 2008 by OCA (Talk | contribs)
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Image:1ddj.gif

Template:STRUCTURE 1ddj

CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN


Overview

Activation of the serine protease plasmin from its zymogen, plasminogen, is the key step in fibrinolysis leading to blood clot dissolution. It also plays critical roles in cell migration, such as in tumor metastasis. Here, we report the crystal structure of an inactive S741A mutant of human plasminogen catalytic domain at 2.0 A resolution. This structure permits a direct comparison with that of the plasmin catalytic unit. Unique conformational differences are present between these two structures that are not seen in other zymogen-enzyme pairs of the trypsin family. The functional significance of these differences and the structural basis of plasminogen activation is discussed in the light of this new structure.

About this Structure

1DDJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human plasminogen catalytic domain undergoes an unusual conformational change upon activation., Wang X, Terzyan S, Tang J, Loy JA, Lin X, Zhang XC, J Mol Biol. 2000 Jan 28;295(4):903-14. PMID:10656799 Page seeded by OCA on Fri May 2 13:43:36 2008

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