1wi0

Structural highlights

Function

[MP2K5_MOUSE] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.^{[1] [2]}

See Also

• Mitogen-activated protein kinase kinase 3D structures

References

1. ↑ Kamakura S, Moriguchi T, Nishida E. Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71. PMID:10473620
2. ↑ Nakamura K, Uhlik MT, Johnson NL, Hahn KM, Johnson GL. PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol Cell Biol. 2006 Mar;26(6):2065-79. PMID:16507987 doi:http://dx.doi.org/26/6/2065