1x57

Structural highlights

Function

[EDF1_HUMAN] Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.^{[1] [2] [3] [4]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA. EDF-1, a novel gene product down-regulated in human endothelial cell differentiation. J Biol Chem. 1998 Nov 20;273(47):31119-24. PMID:9813014
2. ↑ Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi K, Shirakawa M, Hirose S, Handa H. The role of human MBF1 as a transcriptional coactivator. J Biol Chem. 1999 Nov 26;274(48):34196-202. PMID:10567391
3. ↑ Brendel C, Gelman L, Auwerx J. Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism. Mol Endocrinol. 2002 Jun;16(6):1367-77. PMID:12040021 doi:http://dx.doi.org/10.1210/mend.16.6.0843
4. ↑ Ballabio E, Mariotti M, De Benedictis L, Maier JA. The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A. Cell Mol Life Sci. 2004 May;61(9):1069-74. PMID:15112053 doi:http://dx.doi.org/10.1007/s00018-004-4016-0