Sandbox Reserved 1646

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This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Gonadotropin releasing hormone 1 receptor

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ PMID:15240592<\ref>

    Relevance

    One of the main using of the couple GnRH - GnRHR in the medicine field is for fertility preservation (1). Indeed a mutation of the receptor gene sometimes lead to failure of detectable ligand binding

    Structural highlights

    This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. 

 1. Torrealday, S.,  Lalioti, M. D.,  Guzeloglu-Kayisli, O. and Seli, E. (2013), Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female   Mouse Ovary. Endocrinology. doi:  10.1210/en.2013-1341

2. Meysing 1 ,A.U., Kanasaki, H., Bedecarrats,G.Y. Acierno Jr, J.S. Conn, P.M., Martin,K.A., Seminara,S.B., Hall,J.E., Crowley Jr, W.F., Kaiser,U.K. (2004), GNRHR Mutations in a Woman with Idiopathic Hypogonadotropic Hypogonadism Highlight the Differential Sensitivity of Luteinizing Hormone and Follicle-Stimulating Hormone to Gonadotropin-Releasing Hormone. doi : 10.1210/jc.2003-031808

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