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spinqualitylabelsall models Structure of mouse CD1d expressed in SF9 cells, no ligand added Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664.

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CD1 (Cluster of Differentiation 1) is a family of glycoproteins involved in the presentation of antigens on the surface of specific cells to NKT cells. Amongst these CD1-presenting cells can be counted splenic dendritic cells, marginal zone B cells and CD4+CD8+ thymocytes.

This family is made of two main groups: group 1 is composed of CD1a, b and c proteins and group 2 is composed of CD1d proteins. Thus, the structure and function of such proteins in mice are akin to those of humans. Mice doesn’t express group 1 CD1 molecules. Instead, they have two kinds of CD1d molecules. Therefore, they have been widely used to characterize the functions of CD1d and CD1d-dependent NKT cells in many diseases.

Contents 1 Structure of mouse CD1d expressed in SF9 cells, no ligand added 2 Function 3 Structure 4 Impact of ligand-binding 5 Appications 6 References 7 References

Structure of mouse CD1d expressed in SF9 cells, no ligand added

Function

Structure

Impact of ligand-binding

Appications

References

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References