User talk:Daniel Hausaman

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Contents 1 Remdesivir 2 Introduction 3 Function 4 Mechanism 5 Disease 6 Relevance 7 Structural highlights

Remdesivir

Introduction

SARS-CoV-2 also known as severe acute respiratory syndrome coronavirus 2 or COVID-19 is a respiratory disease that is capable of progressing to viral pneumonia and can also lead to death. SARS-Cov2 relies upon RNA-dependent RNA polymerase (RdRp) to replicate the viral genetic material. Drugs such as nucleoside analogues can be used to inhibit this enzyme and stop viral replication. Remdesivir initially labeled GS-5734 is an adenosine triphosphate analogue, used as a broad-spectrum antiviral drug meaning it can be used to inhibit a wide range of viruses that rely upon RNA-dependent RNA polymerase for genomic replication.

Function

Mechanism

Disease

Relevance

Structural highlights

spinqualitylabelsall models The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

== References