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Somatotropin and Genetic origin
Somatotropin is a polypeptide hormone produced by the somatotropic cells of the pituitary gland. Growth hormone, a protein circulating in the blood.
The Human Growth Hormone has its origin on chromosome 17. There it gets encoded by the Growth hormone 1 gene along with four other related genes. Three of these genes are encoding human chorionic somatomammotropin, which is closely related to somatotropin. They are all in the same transcriptional orientation.
Functions
Somatropin plays an important role in physiological environments such as: increasing muscle mass, reducing fat mass, providing the energy necessary for tissue growth, maintaining the right level of glucose and lipids ... and the development of the individual's body [1]. It acts directly on a cell surface or indirectly [1]. In the second case, somatropin stimulates tissues such as the liver, which in turn allows the synthesis and secretion of IGF-1, thus enabling the development of cell growth, tissue, bone and thus the linear growth of the individual [2].
Relevance
Structural highlights
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