Nuclear receptor

From Proteopedia

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the nuclear receptors facts book ^[1]

Structure

DBD (DNA Binding Domain)

LBD (Ligand Binding Domain)

spinqualitylabelsall models Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry 1ie8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image The structure of the LBD is strongly conserved throughout the familly of nuclear receptors. It is a globular domain, mainly alpha composed of arranged in a three layered sandwich, and a .

Family members:

• Androgen receptor
• Estrogen Receptor-like
  • Estrogen receptor
  • Estrogen-related receptor
• Peroxisome Proliferator-Activated Receptors
• Vitamin D receptor

1. ↑ Vincent Laudet, Hinrich Gronemeyer, "The nuclear receptor factsbook", Publisher Academic Press, 2002