Function
TRAP dicarboxylate transporter, DctP subunit is part of the tripartite ATP-dependent transporters which consist of three protiens: DctP, DctM and DctQ. DctP is a periplasmic C4-dicarboxylate-binding receptor[1].
Disease
RPE1 has been shown to mitigate host cell defenses leading to the development of cancer induces apoptosis of its host cells[2].
Relevance
The detection of RPE1 mRNA and promoter methylation may serve as cancer prognostic marker.
Structural highlights
The complex between BPV1 DBD and 21-bp DNA (PDB code 1ksx) shows 2 DBD-DNA binding modules: a binding loop and a binding helix each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones[3].
