2ecj

Structural highlights

Function

[TRI39_HUMAN] E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Lee SS, Fu NY, Sukumaran SK, Wan KF, Wan Q, Yu VC. TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. Exp Cell Res. 2009 Apr 15;315(7):1313-25. doi: 10.1016/j.yexcr.2008.11.021. Epub , 2008 Dec 9. PMID:19100260 doi:http://dx.doi.org/10.1016/j.yexcr.2008.11.021
2. ↑ Huang NJ, Zhang L, Tang W, Chen C, Yang CS, Kornbluth S. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. J Cell Biol. 2012 Apr 30;197(3):361-7. doi: 10.1083/jcb.201108062. Epub 2012 Apr , 23. PMID:22529100 doi:http://dx.doi.org/10.1083/jcb.201111141