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Contents 1 Lipoprotein Lipase (LPL) complexed with GPIHBP1 1.1 Disease 1.1.1 Mutations 1.1.1.1 D201V 1.1.1.2 M404R 1.2 Relevance 1.2.1 Hypertriglycerademia 1.2.2 Drug Relevance 1.3 References 1.4 Student/Contributors

Lipoprotein Lipase (LPL) complexed with GPIHBP1

spinqualitylabelsall models Lipoprotein Lipase - 6E7K Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Introduction 1.1 History 1.2 Significance 1.3 General Function 2 Structure 2.1 Overall Structure 2.2 LPL 2.2.1 N-terminus of LPL 2.2.1.1 Calcium Ion Coordination 2.2.2 C-terminus of LPL 2.2.2.1 GPIHBP1 2.3 Active Site 2.3.1 Mechanism Introduction History Significance General Function [1] Structure Overall Structure LPL N-terminus of LPL Calcium Ion Coordination C-terminus of LPL GPIHBP1 Active Site Mechanism

Disease

Mutations

D201V

M404R

Relevance

Hypertriglycerademia

Drug Relevance

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References

1. ↑ Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2018 Dec 17. pii: 1817984116. doi:, 10.1073/pnas.1817984116. PMID:30559189 doi:http://dx.doi.org/10.1073/pnas.1817984116

Student/Contributors

• Ashrey Burely
• Allison Welz
• Hannah Wright