Diacylglycerol acyltransferase (DGAT) catalyzes the final and only committed step of triacylglycerol synthesis.2 It does this by using diacylglycerol (DAG) and oleoyl CoA as substrates. DGAT plays a pivotal role in the metabolism of DAG and is important to the process of triacylglycerol metabolism. This metabolism is involved in intestinal fat absorption, lipoprotein assembly, lactation, and adipose tissue formation.1

Figure 1

Function

DGAT1 is a membrane protein responsible for the conversion of diacylglycerols to triacylglycerols.

Disease

Relevance

Structural highlights

Active Site

Tunnel System

Mechanism

The catalytic His415 deprotonates the hydroxyl group on the glycerol backbone of

Transition State Stabilization

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