1a7x

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Image:1a7x.gif

1a7x, resolution 2.0Å

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FKBP12-FK1012 COMPLEX

Overview

A ligand that simultaneously binds two proteins must have two high, affinity protein binding domains joined in a fashion that facilitates, or, at least does not prevent, protein-protein interaction. Designing such, ligands is challenging, and a high resolution X-ray structure of, FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.

About this Structure

1A7X is a Single protein structure of sequence from Homo sapiens with FKA as ligand. Active as Peptidylprolyl isomerase, with EC number 5.2.1.8 Full crystallographic information is available from OCA.

Reference

Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:9871618

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