Isopeptide bond

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See Isopeptide bond in Wikipedia.

A search for isopeptide bond in the keywords records at the PDB returns over 200 hits (April, 2021).

The capsid of the HK97 bacteriophage contains isopeptide bonds that cross-link the protein chains into a protein chain mail ^[1][2][3].

Examples:

• 7cap is a ubiquitin homotrimer. The C-terminal Gly76 is isopeptide linked to Lys48 in each inter-chain interface.

References

1. ↑ Hendrix RW, Johnson JE. Bacteriophage HK97 capsid assembly and maturation. Adv Exp Med Biol. 2012;726:351-63. doi: 10.1007/978-1-4614-0980-9_15. PMID:22297521 doi:10.1007/978-1-4614-0980-9_15
2. ↑ Gilakjan ZA, Kropinski AM. Cloning and analysis of the capsid morphogenesis genes of Pseudomonas aeruginosa bacteriophage D3: another example of protein chain mail? J Bacteriol. 1999 Dec;181(23):7221-7. PMID:10572124
3. ↑ Dierkes LE, Peebles CL, Firek BA, Hendrix RW, Duda RL. Mutational analysis of a conserved glutamic acid required for self-catalyzed cross-linking of bacteriophage HK97 capsids. J Virol. 2009 Mar;83(5):2088-98. doi: 10.1128/JVI.02000-08. Epub 2008 Dec 17. PMID:19091865 doi:10.1128/JVI.02000-08