Neurotrophin-4 (NT-4) is a neuronal growth factor that influences nerve cell proliferation through selective and non-covalent interactions with the nerve growth factor receptor.
Function
NT-4 functions as a growth factor in many biological pathways and processes to induce neuronal proliferation.
Biological Processes
Positive regulation of neurotrophin TRK receptor signaling pathway:
NT-4 functions as a ligand when binding to neurotrophin receptor tyrosine kinase NTRK2. Auto-phosphorylated NTRK2 dimers that are formed on tyrosine residues in receptor tail as a result of NT-4 binding.
Neuron projection morphogenesis:
Generating projection structures of a neuron,.
Ganglion mother cell fate determination, epidermis development, innervation
Nerve invading tissue and coming out
Disease
NT-4, along with other growth factors including neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) have all shown to be essential for survival of neurons. These growth factors have also been associated with parts of the cerebrum including the frontal lobe and limbic system because of their involvement in neurological processes like behavior, learning, and memory. [1]
Relevance
Structural highlights
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