2iuz
From Proteopedia
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH C2-DICAFFEINE
Overview
Family 18 chitinases play key roles in the life cycles of a variety of, organisms ranging from bacteria to man. Very recently it has been shown, that one of the mammalian chitinases is highly overexpressed in the, asthmatic lung and contributes to the pathogenic process through, recruitment of inflammatory cells. Although several potent natural product, chitinase inhibitors have been identified, their chemotherapeutic, potential or their use as cell biological tools is limited due to their, size, complex chemistry, and limited availability. We describe a virtual, screening-based approach to identification of a novel, purine-based, chitinase inhibitor. This inhibitor acts in the low micromolar, (Ki=2.8+/-0.2 microM) range in a competitive mode. Dissection of the, binding mode by x-ray ... [(full description)]
About this Structure
2IUZ is a [Single protein] structure of sequence from [Aspergillus fumigatus] with SO4 and D1H as [ligands]. Active as [[1]], with EC number [3.2.1.14]. Full crystallographic information is available from [OCA].
Reference
Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor., Schuttelkopf AW, Andersen OA, Rao FV, Allwood M, Lloyd C, Eggleston IM, van Aalten DM, J Biol Chem. 2006 Sep 15;281(37):27278-85. Epub 2006 Jul 14. PMID:16844689
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