1aml
From Proteopedia
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THE ALZHEIMER`S DISEASE AMYLOID A4 PEPTIDE (RESIDUES 1-40)
Contents |
Overview
One of the principle peptide components of the amyloid plaque deposits of, Alzheimer's disease in humans is the 40-amino-acid peptide beta-amyloid, A4-(1-40)-peptide. The full-length A4-(1-40)-peptide was chemically, synthesized and the solution structure determined by two-dimensional, nuclear magnetic resonance spectroscopy and restrained molecular-dynamics, calculations. Synthetic human A4-(1-40)-peptide was soluble and, non-aggregating for several days in 40% (by vol.) trifluoroethanol/water., All spin systems could be unambiguously assigned, and a total of 203, sequential and medium-range cross-peaks were found in the NOESY (nuclear, Overhauser enhancement spectroscopy) spectrum. Long-range NOE cross-peaks, that would indicate tertiary structure of the peptide were absent. The, main secondary-structure elements found by chemical-shift analysis, sequential and medium-range NOESY data, and NOE-based restrained, molecular-dynamics calculations were two helices, Gln15-Asp23 and, Ile31-Met35, whereas the rest of the peptide was in random-coil, conformation. A similar secondary structure is suggested for the, aggregation part of prions, the postulated causative agents of the, transmissible spongiform encephalopathy. The sequence of the helical part, of prion proteins was observed to be remarkably similar to the sequence of, the helical part of human A4-(1-40)-peptide.
Disease
Known diseases associated with this structure: Alzheimer disease-1, APP-related OMIM:[104760], Amyloidosis, cerebroarterial, Dutch type OMIM:[104760], Amyloidosis, cerebroarterial, Iowa type OMIM:[104760], Blood group, P system OMIM:[607922]
About this Structure
1AML is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease., Sticht H, Bayer P, Willbold D, Dames S, Hilbich C, Beyreuther K, Frank RW, Rosch P, Eur J Biochem. 1995 Oct 1;233(1):293-8. PMID:7588758
Page seeded by OCA on Mon Nov 12 15:59:59 2007
