1atn

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spinqualitylabelsall models 1atn, resolution 2.8Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

ATOMIC STRUCTURE OF THE ACTIN:DNASE I COMPLEX

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The atomic models of the complex between rabbit skeletal muscle actin and, bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have, been determined by X-ray analysis at an effective resolution of 2.8 A and, 3A, respectively. The two structures are very similar. The actin molecule, consists of two domains which can be further subdivided into two, subdomains. ADP or ATP is located in the cleft between the domains with a, calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta, meander and a right handed beta alpha beta unit appears in each domain, suggesting that gene duplication might have occurred. These sheets have, the same topology as that found in hexokinase.

Disease

Known diseases associated with this structure: Myopathy, actin, congenital, with cores OMIM:[102610], Myopathy, actin, congenital, with excess of thin myofilaments OMIM:[102610], Myopathy, congenital, with fiber-type disporportion 1 OMIM:[102610], Myopathy, nemaline, 3 OMIM:[102610]

About this Structure

1ATN is a Protein complex structure of sequences from Bos taurus and Oryctolagus cuniculus with CA, ACE, CH3 and ATP as ligands. The following pages contain interesting information on the relation of 1ATN with [Actin]. Full crystallographic information is available from OCA.

Reference

Atomic structure of the actin:DNase I complex., Kabsch W, Mannherz HG, Suck D, Pai EF, Holmes KC, Nature. 1990 Sep 6;347(6288):37-44. PMID:2395459

Page seeded by OCA on Mon Nov 12 16:01:39 2007