Structural highlights
Publication Abstract from PubMed
Rocky Mountain spotted fever is caused by Rickettsia rickettsii infection. R. rickettsii can be transmitted to mammals, including humans, through the bite of an infected hard-bodied tick of the family Ixodidae. Since the R. rickettsii genome contains only one cold-shock-like protein and given the essential nature of cold-shock proteins in other bacteria, the structure of the cold-shock-like protein from R. rickettsii was investigated. With the exception of a short alpha-helix found between beta-strands 3 and 4, the solution structure of the R. rickettsii cold-shock-like protein has the typical Greek-key five-stranded beta-barrel structure found in most cold-shock domains. Additionally, the R. rickettsii cold-shock-like protein, with a DeltaG of unfolding of 18.4 kJ mol(-1), has a similar stability when compared with other bacterial cold-shock proteins.
Solution structure of the cold-shock-like protein from Rickettsia rickettsii.,Gerarden KP, Fuchs AM, Koch JM, Mueller MM, Graupner DR, O'Rorke JT, Frost CD, Heinen HA, Lackner ER, Schoeller SJ, House PG, Peterson FC, Veldkamp CT Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1284-8., doi: 10.1107/S174430911203881X. Epub 2012 Oct 26. PMID:23143233[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Gerarden KP, Fuchs AM, Koch JM, Mueller MM, Graupner DR, O'Rorke JT, Frost CD, Heinen HA, Lackner ER, Schoeller SJ, House PG, Peterson FC, Veldkamp CT. Solution structure of the cold-shock-like protein from Rickettsia rickettsii. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1284-8., doi: 10.1107/S174430911203881X. Epub 2012 Oct 26. PMID:23143233 doi:http://dx.doi.org/10.1107/S174430911203881X
