1axc

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spinqualitylabelsall models 1axc, resolution 2.6Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

HUMAN PCNA

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The crystal structure of the human DNA polymerase delta processivity, factor PCNA (proliferating cell nuclear antigen) complexed with a 22, residue peptide derived from the C-terminus of the cell-cycle checkpoint, protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution. p21, binds to PCNA in a 1:1 stoichiometry with an extensive array of, interactions that include the formation of a beta sheet with the, interdomain connector loop of PCNA. An intact trimeric ring is maintained, in the structure of the p21-PCNA complex, with a central hole available, for DNA interaction. The ability of p21 to inhibit the action of PCNA is, therefore likely to be due to its masking of elements on PCNA that are, required for the binding of other components of the polymerase assembly.

Disease

Known disease associated with this structure: Multiple endocrine neoplasia, type IV OMIM:[600778]

About this Structure

1AXC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA., Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J, Cell. 1996 Oct 18;87(2):297-306. PMID:8861913

Page seeded by OCA on Mon Nov 12 16:03:28 2007