1b4f
From Proteopedia
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OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTOR SAM DOMAIN
Contents |
Overview
The sterile alpha motif (SAM) domain is a protein interaction module that, is present in diverse signal-transducing proteins. SAM domains are known, to form homo- and hetero-oligomers. The crystal structure of the SAM, domain from an Eph receptor tyrosine kinase, EphB2, reveals two large, interfaces. In one interface, adjacent monomers exchange amino-terminal, peptides that insert into a hydrophobic groove on each neighbor. A second, interface is composed of the carboxyl-terminal helix and a nearby loop. A, possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes.
Disease
Known diseases associated with this structure: Prostate cancer, progression and metastasis of OMIM:[600997]
About this Structure
1B4F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Oligomeric structure of the human EphB2 receptor SAM domain., Thanos CD, Goodwill KE, Bowie JU, Science. 1999 Feb 5;283(5403):833-6. PMID:9933164
Page seeded by OCA on Mon Nov 12 16:05:35 2007
