2r8t

Structural highlights

Function

[GLPX_ECOLI] Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Is likely to be involved in gluconeogenesis during growth on glycerol. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5-bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Fructose-1%2C6-bisphosphatase 3D structures

References

1. ↑ Donahue JL, Bownas JL, Niehaus WG, Larson TJ. Purification and characterization of glpX-encoded fructose 1, 6-bisphosphatase, a new enzyme of the glycerol 3-phosphate regulon of Escherichia coli. J Bacteriol. 2000 Oct;182(19):5624-7. PMID:10986273
2. ↑ Brown G, Singer A, Lunin VV, Proudfoot M, Skarina T, Flick R, Kochinyan S, Sanishvili R, Joachimiak A, Edwards AM, Savchenko A, Yakunin AF. Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli. J Biol Chem. 2009 Feb 6;284(6):3784-92. Epub 2008 Dec 10. PMID:19073594 doi:10.1074/jbc.M808186200