Histidine-tyrosine protein crosslinks

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Covalent bonds between histidine and tyrosine form in some c-type cytochromes[1][2][3] and catalases, making crosslinks between polypeptide chains near the catalytic sites.

References and Notes

  1. Tsukihara T, Shimokata K, Katayama Y, Shimada H, Muramoto K, Aoyama H, Mochizuki M, Shinzawa-Itoh K, Yamashita E, Yao M, Ishimura Y, Yoshikawa S. The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15304-9. Epub 2003 Dec 12. PMID:14673090 doi:10.1073/pnas.2635097100
  2. Although His-Tyr bonds are present in 1v54 and 1v55 published by Tsukihara et al., no mention of them is made in their 2003 paper.
  3. Buse G, Soulimane T, Dewor M, Meyer HE, Bluggel M. Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase. Protein Sci. 1999 May;8(5):985-90. PMID:10338009 doi:http://dx.doi.org/10.1110/ps.8.5.985

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