Growth factors

From Proteopedia

spinqualitylabelsall models Platelet-Derived Growth Factor Receptor (brown and turquoise) complex with Platelet-Derived Growth Factor B (grey and green) (PDB code 3mjg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Activin receptor 3D structure of the kinase domain of Activin receptor1 (Acvr1) complex with inhibitor shows with the protein including a and a [1]. Water molecule is shown as red sphere. Autocrine motility factor Rabbit [2]. Water molecules are shown as red spheres. Bone morphogenetic protein. For details on BMP-7 see Student Projects for UMass Chemistry 423 Spring 2012-4. Colony-stimulating factor and Colony-stimulating factor receptor The structure of the complex between M-CSF and its receptor shows that a . There are [3]. . The via the conserved kinase DFG motif (colored in salmon) and its gatekeeper threonine residue (colored in magenta)[4]. Epidermal growth factor and Epidermal Growth Factor Receptor Ephrin and Ephrin receptor Erythropoietin and Erythropoietin receptor Fibroblast growth factor and Fibroblast growth factor receptor Growth differentiation factor Hepatocyte growth factor and Hepatocyte growth factor receptor Insulin and Insulin receptor Insulin-like growth factor and Insulin-like growth factor receptor IGF1 Interleukin Neurotrophin High affinity nerve growth factor receptor TrkB tyrosine kinase receptor Platelet-derived growth factors and receptors Renalase (RNLS) – Anti-apoptotic survival factor Tumor necrosis factor Tumor necrosis factor receptor Tumor necrosis factor ligand superfamily Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor Transforming Growth Factor and its receptor See also: Hormones and their receptors Receptor

References

1. ↑ Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15. doi: 10.1021/jm501177w. Epub 2014 Sep 4. PMID:25101911 doi:http://dx.doi.org/10.1021/jm501177w
2. ↑ Lee JH, Chang KZ, Patel V, Jeffery CJ. Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate. Biochemistry. 2001 Jul 3;40(26):7799-805. PMID:11425306
3. ↑ Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN. Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure. 2015 Jul 21. pii: S0969-2126(15)00272-5. doi:, 10.1016/j.str.2015.06.019. PMID:26235028 doi:http://dx.doi.org/10.1016/j.str.2015.06.019
4. ↑ Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, Oh A, Bremer R, Hurt CR, Artis DR, Wu G, Nespi M, Spevak W, Lin P, Nolop K, Hirth P, Tesch GH, Bollag G. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc Natl Acad Sci U S A. 2013 Mar 14. PMID:23493555 doi:http://dx.doi.org/10.1073/pnas.1219457110