This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1bj8
From Proteopedia
|
THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
The transmembrane glycoprotein gp130 is the common signal transducing, receptor subunit of the interleukin-6-type cytokines. It is a member of, the cytokine-receptor superfamily predicted to consist of six domains in, its extracellular part. The second and third domain constitute the, cytokine-binding module defined by a set of four conserved cysteines and a, WSXWS motif, respectively. The three-dimensional structure of the, carboxy-terminal domain of this region was determined by multidimensional, NMR. The domain consists of seven beta-strands constituting a fibronectin, type III-like topology. The structure reveals that the WSDWS motif of, gp130 is part of an extended tryptophan/arginine zipper which modulates, the conformation of the CD loop.
About this Structure
1BJ8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:10210178
Page seeded by OCA on Mon Nov 12 16:10:43 2007
Categories: Homo sapiens | Single protein | Dijkstra, K. | Grotzinger, J. | Grzesiek, S. | Heinrich, P.C. | Kernebeck, T. | Kurapkat, G. | Muller-Newen, G. | Pflanz, S. | Scheek, R.M. | Wollmer, A. | Glycoprotein | Receptor | Signal transducer of il-6 type cytokines | Third n-terminal domain | Transmembrane
