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1bp3
From Proteopedia
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THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
Contents |
Overview
The human pituitary hormones, growth hormone (hGH) and prolactin (hPRL), regulate a large variety of physiological processes, among which are, growth and differentiation of muscle, bone and cartilage cells, and, lactation. These activities are initiated by hormone-receptor binding. The, hGH and hPRL receptors (hGHR and hPRLR, respectively) are single-pass, transmembrane receptors from class 1 of the haematopoietic receptor, superfamily. This classification is based on sequence similarity in their, extracellular domains, notably a highly conserved pentapeptide, the, so-called 'WSXWS box', the function of which is controversial. All ligands, in class 1 activate their respective receptors by clustering mechanisms., In the case of hGH, activation involves receptor homodimerization in a, sequential process: the active ternary complex containing one ligand and, two receptor molecules is formed by association of a receptor molecule to, an intermediate 1:1 complex. hPRL does not bind to the hGH receptor, but, hGH binds to both the hGHR and hPRLR, and mutagenesis studies have shown, that the receptor-binding sites on hGH overlap. We present here the, crystal structure of the 1:1 complex of hGH bound to the extracellular, domain of the hPRLR. Comparisons with the hGH-hGHR complex reveal how hGH, can bind to the two distinctly different receptor binding surfaces.
Disease
Known diseases associated with this structure: Growth hormone deficiency OMIM:[139250], Growth hormone deficiency, isolated, type IA OMIM:[139250], Growth hormone deficiency, isolated, type IB OMIM:[139250], Growth hormone deficiency, isolated, type II OMIM:[139250], Kowarski syndrome OMIM:[139250], Short stature, familial OMIM:[139250]
About this Structure
1BP3 is a Protein complex structure of sequences from Homo sapiens with ZN as ligand. Full crystallographic information is available from OCA.
Reference
The X-ray structure of a growth hormone-prolactin receptor complex., Somers W, Ultsch M, De Vos AM, Kossiakoff AA, Nature. 1994 Dec 1;372(6505):478-81. PMID:7984244
Page seeded by OCA on Mon Nov 12 16:13:16 2007
