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Function of your protein
Converts P5C to proline. When complexed with NFLP, NFLP inhibits this function, interrupting the proline cycle in cancerous cells, and decreasing spheroid growth. [3]
Biological relevance and broader implications
PYCR-1 has been shown to have have many effects on the survival and proliferation of cancerous cells when the proline cycle is able to continue [4]. NFLP is a competitive inhibitor of PYCR-1. When NFLP is able to bind it changes the conformation of the protein, which in turn makes it unable to convert P5C to proline, and disrupts the proline cycle [5]. In this way, NFLP shows potential for further research into reducing the success of cancerous cells. Since NFLP is a competitive inhibitor, this means that some PYCR-1 protein will still bind P5C and partake in the proline cycle. NFLP then shows promise to reduce, but not eliminate the proliferation of cancer. Research should be done into any analogs of NFLP which could prove to be more successful inhibitors.
Important amino acids
Histidine 223, Asparagine 229, Valine 231, Serine 233, and Alanine 237.
Structural highlights
Other important features
