1by2

From Proteopedia

Revision as of 14:08, 12 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:1by2.gif

1by2, resolution 2.00Å

Drag the structure with the mouse to rotate

STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN

Overview

Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell, surface molecules and in some secreted proteins, where they are thought to, mediate ligand binding. We have determined the crystal structure at 2.0 A, resolution of the SRCR domain of Mac-2 binding protein (M2BP), a, tumor-associated antigen and matrix protein. The structure reveals a, curved six-stranded beta-sheet cradling an alpha-helix. Structure-based, sequence alignment demonstrates that the M2BP SRCR domain is a valid, template for the entire SRCR protein superfamily. This allows an, interpretation of previous mutagenesis data on ligand binding to the, lymphocyte receptor CD6.

About this Structure

1BY2 is a Single protein structure of sequence from Homo sapiens with NAG as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily., Hohenester E, Sasaki T, Timpl R, Nat Struct Biol. 1999 Mar;6(3):228-32. PMID:10074941

Page seeded by OCA on Mon Nov 12 16:15:20 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1by2"
Personal tools