1bzg
From Proteopedia
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THE SOLUTION STRUCTURE OF HUMAN PARATHYROID HORMONE-RELATED PROTEIN (1-34) IN NEAR-PHYSIOLOGICAL SOLUTION, NMR, 30 STRUCTURES
Contents |
Overview
Parathyroid hormone-related protein plays a major role in the pathogenesis, of humoral hypercalcemia of malignancy. Under normal physiological, conditions, parathyroid hormone-related protein is produced in a wide, variety of tissues and acts in an autocrine or paracrine fashion., Parathyroid hormone-related protein and parathyroid hormone bind to and, activate the same G-protein-coupled receptor. Here we present the, structure of the biologically active NH2-terminal domain of human, parathyroid hormone-related protein(1-34) in near-physiological solution, in the absence of crowding reagents as determined by two-dimensional, proton magnetic resonance spectroscopy. An improved strategy for structure, calculation revealed the presence of two helices, His-5-Leu-8 and, Gln-16-Leu-27, connected by a flexible linker. The parathyroid, hormone-related protein(1-34) structure and the structure of human, parathyroid hormone(1-37) as well as human parathyroid hormone(1-34) are, highly similar, except for the well defined turn, His-14-Ser-17, present, in parathyroid hormone. Thus, the similarity of the binding affinities of, parathyroid hormone and parathyroid hormone-related protein to their, common receptor may be based on their structural similarity.
Disease
Known disease associated with this structure: Humoral hypercalcemia of malignancy (1) OMIM:[168470]
About this Structure
1BZG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution., Weidler M, Marx UC, Seidel G, Schafer W, Hoffmann E, Esswein A, Rosch P, FEBS Lett. 1999 Feb 12;444(2-3):239-44. PMID:10050767
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