Disease
Influenza A causes the infectious respiratory disease Influenza, more commonly known as the Flu.[1] Influenza has several symptoms associated with it: fever, sore throat, runny nose, headache, muscle pain, and fatigue to severe and in some cases lethal pneumonia resultant from either influenza virus or bacterial infection in the lower respiratory tract.[2] The CDC estimated in 2019-2020 that the overall burden of Influenza was 35 million Flu-related illnesses, 16 million Flu-related medical visits, 380,000 Flu-related hospitalizations, and 20,000 Flu-related deaths [1]. The WHO estimated the global impact of annual Flu epidemics resulted in 3 to 5 million cases of severe illness, and about 290,000 to 650,000 respiratory deaths [2]. Multiple types of vaccines against Influenza currently exist: inactivated influenza vaccines (IIV4s), recombinant influenza vaccine (RIV4), and live attenuated influenza vaccine (LAIV4).[3]
Viral RNA Classification
Function of RNA Dependent RNA Polymerases
Structural Features
Viral RNA Transcription and Translation
Conservation within Influenza A RDRP
Possible Scenes
1) Scene that shows the nucleotide entry site
2) Scene showing conserved motifs/ residues
3) Scene showing the catalytic site (space-filling to show how things fit)
4) Scene that colors the different subunits, such as PB1
5) Scene that shows the areas that undergo conformation changes, maybe even a scene that shows what the conformation changes are like
