Structural highlights
Disease
[CCG2_MOUSE] Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.
Function
[DLG3_RAT] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity). [CCG2_MOUSE] Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.
Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions.,Sainlos M, Iskenderian-Epps WS, Olivier NB, Choquet D, Imperiali B J Am Chem Soc. 2013 Mar 27;135(12):4580-3. doi: 10.1021/ja309870q. Epub 2013 Mar , 13. PMID:23480637[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Sainlos M, Iskenderian-Epps WS, Olivier NB, Choquet D, Imperiali B. Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions. J Am Chem Soc. 2013 Mar 27;135(12):4580-3. doi: 10.1021/ja309870q. Epub 2013 Mar , 13. PMID:23480637 doi:http://dx.doi.org/10.1021/ja309870q
