| Structural highlights
7dhw is a 1 chain structure with sequence from Arath. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , , |
| Gene: | XI-2, MYA2, At5g43900, F6B6.4 (ARATH) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[MYO6_ARATH] Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in the tip growth of root hair cells. Plays a major role in trafficking of Golgi stacks, mitochondria and peroxisomes during root hair development. Targets the peroxisome through an interaction with RABC2A. Required for development of pavement cells, trichomes, and stigmatic papillae.[1] [2] [3] [4] [5] [6] [7]
References
- ↑ Hashimoto K, Igarashi H, Mano S, Nishimura M, Shimmen T, Yokota E. Peroxisomal localization of a myosin XI isoform in Arabidopsis thaliana. Plant Cell Physiol. 2005 May;46(5):782-9. doi: 10.1093/pcp/pci085. Epub 2005 Mar , 25. PMID:15792961 doi:http://dx.doi.org/10.1093/pcp/pci085
- ↑ Peremyslov VV, Prokhnevsky AI, Avisar D, Dolja VV. Two class XI myosins function in organelle trafficking and root hair development in Arabidopsis. Plant Physiol. 2008 Mar;146(3):1109-16. doi: 10.1104/pp.107.113654. Epub 2008 Jan, 4. PMID:18178669 doi:http://dx.doi.org/10.1104/pp.107.113654
- ↑ Prokhnevsky AI, Peremyslov VV, Dolja VV. Overlapping functions of the four class XI myosins in Arabidopsis growth, root hair elongation, and organelle motility. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19744-9. doi:, 10.1073/pnas.0810730105. Epub 2008 Dec 5. PMID:19060218 doi:http://dx.doi.org/10.1073/pnas.0810730105
- ↑ Avisar D, Abu-Abied M, Belausov E, Sadot E, Hawes C, Sparkes IA. A comparative study of the involvement of 17 Arabidopsis myosin family members on the motility of Golgi and other organelles. Plant Physiol. 2009 Jun;150(2):700-9. doi: 10.1104/pp.109.136853. Epub 2009 Apr, 15. PMID:19369591 doi:http://dx.doi.org/10.1104/pp.109.136853
- ↑ Peremyslov VV, Prokhnevsky AI, Dolja VV. Class XI myosins are required for development, cell expansion, and F-Actin organization in Arabidopsis. Plant Cell. 2010 Jun;22(6):1883-97. doi: 10.1105/tpc.110.076315. Epub 2010 Jun, 25. PMID:20581304 doi:http://dx.doi.org/10.1105/tpc.110.076315
- ↑ Avisar D, Abu-Abied M, Belausov E, Sadot E. Myosin XIK is a major player in cytoplasm dynamics and is regulated by two amino acids in its tail. J Exp Bot. 2012 Jan;63(1):241-9. doi: 10.1093/jxb/err265. Epub 2011 Sep 13. PMID:21914656 doi:http://dx.doi.org/10.1093/jxb/err265
- ↑ Ojangu EL, Tanner K, Pata P, Jarve K, Holweg CL, Truve E, Paves H. Myosins XI-K, XI-1, and XI-2 are required for development of pavement cells, trichomes, and stigmatic papillae in Arabidopsis. BMC Plant Biol. 2012 Jun 6;12:81. doi: 10.1186/1471-2229-12-81. PMID:22672737 doi:http://dx.doi.org/10.1186/1471-2229-12-81
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