1cd8
From Proteopedia
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CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION
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Overview
A secreted fragment of the extracellular portion of human CD8 alpha has, been expressed in CHO cells, and a deglycosylated and proteolyzed form of, this fragment has been crystallized. We report here the crystal structure, of this fragment as refined at 2.6 A resolution. The structure was solved, by molecular replacement using a superposition of ten variable domains, from immunoglobulin light chains as the search model. Only the N-terminal, 114 amino acids of CD8 alpha are visible in the electron density maps. The, domain formed by these residues possesses a fold typical of immunoglobulin, variable domains and associates to form Fv-like homodimers.
Disease
Known disease associated with this structure: Megakaryoblastic leukemia, acute OMIM:[606078]
About this Structure
1CD8 is a Single protein structure of sequence from [1] with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution., Leahy DJ, Axel R, Hendrickson WA, Cell. 1992 Mar 20;68(6):1145-62. PMID:1547508
Page seeded by OCA on Mon Nov 12 16:20:16 2007
