Structural highlights
Publication Abstract from PubMed
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
A novel RNA pentaloop fold involved in targeting ADAR2.,Stefl R, Allain FH RNA. 2005 May;11(5):592-7. PMID:15840813[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Stefl R, Allain FH. A novel RNA pentaloop fold involved in targeting ADAR2. RNA. 2005 May;11(5):592-7. PMID:15840813 doi:11/5/592
