GABAA receptors, which is considered ligand-gated ion channels as the binding of GABA results in the opening of ion channels leading to the inhibition of a neuronal signal. Excitatory neurosteroids have excitatory effects on neurotransmission. They act as potent negative allosteric modulators of the GABAA receptor. Major examples include the pregnanes pregnenolone sulfate (PS), epipregnanolone, and isopregnanolone (sepranolone).
GABAA receptor 3D structures
- 6d1s – hGABAA subunit α-1 - human
- 4cof – hGABAA subunit β-3
- 7a5v – hGABAA subunit β-3 + megabody – Cryo EM
- 6i53, 6hup, 6huo, 6huk, 6huj, 6hug – hGABAA subunits α-1+β-3+γ-2 + megabody – Cryo EM
- 6d6u, 6d6t – hGABAA subunits α-1+β-3+γ-2 + antibody + GABA + antagonist – Cryo EM
- 6x3s, 6x3t, 6x3u, 6x3v, 6x3w, 6x3x, 6x40 – hGABAA subunits α-1+β-2+γ-2 + antibody + GABA + antagonist – Cryo EM
- 6a96 – hGABAA subunits β-3 +α-5 + nanobody + GABA – Cryo EM
- 6cdu – hGABAA subunit α-1 + alphaxalone
- 6hsn – rGABAA subunit α-3 + gephyrin + ADP - rat
- 6dw1, 6dw0 – rGABAA subunits α-1+β-1+γ-2 + GABA – Cryo EM
- 7cdb – GABAA subunit γ-2 + GABA receptor-associated protein-like 1 - mouse
