1cok
From Proteopedia
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STRUCTURE OF THE C-TERMINAL DOMAIN OF P73
Contents |
Overview
p73 and p63 are two recently cloned genes with homology to the tumor, suppressor p53, whose protein product is a key transcriptional regulator, of genes involved in cell cycle arrest and apoptosis. While all three, proteins share conserved transcriptional activation, DNA-binding and, oligomerization domains, p73 and p63 have an additional conserved, C-terminal region. We have determined the three-dimensional solution, structure of this conserved C-terminal domain of human p73. The structure, reveals a small five-helix bundle with striking similarity to the SAM, (sterile alpha motif) domains of two ephrin receptor tyrosine kinases. The, SAM domain is a putative protein-protein interaction domain found in a, variety of cytoplasmic signaling proteins and has been shown to form both, homo- and hetero-oligomers. However, the SAM-like C-terminal domains of, p73 and p63 are monomeric and do not interact with one another, suggesting, that this domain may interact with additional, as yet uncharacterized, proteins in a signaling and/or regulatory role.
Disease
Known disease associated with this structure: Neuroblastoma (1) OMIM:[601990]
About this Structure
1COK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:10449409
Page seeded by OCA on Mon Nov 12 16:24:16 2007
