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1csg
From Proteopedia
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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
Contents |
Overview
The crystal structure of recombinant human granulocyte-macrophage, colony-stimulating factor (rhGM-CSF) has been determined at 2.8 A, resolution using multiple isomorphous replacement techniques. There are, two molecules in the crystallographic asymmetric unit, which are related, by an approximate non-crystallographic 2-fold axis. The overall structure, is highly compact and globular with a predominantly hydrophobic core. The, main structural feature of rhGM-CSF is a four alpha-helix bundle, which, represents approximately 42% of the structure. The helices are arranged in, a left-handed antiparallel bundle with two overhand connections. Within, the connections is a two-stranded antiparallel beta-sheet. The tertiary, structure of rhGM-CSF has a topology similar to that of porcine growth, factor and interferon-beta. Most of the proposed critical regions for, receptor binding are located on a continuous surface at one end of the, molecule that includes the C terminus.
Disease
Known disease associated with this structure: Leukemia, acute myeloid, M2 type OMIM:[306250]
About this Structure
1CSG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor., Walter MR, Cook WJ, Ealick SE, Nagabhushan TL, Trotta PP, Bugg CE, J Mol Biol. 1992 Apr 20;224(4):1075-85. PMID:1569568
Page seeded by OCA on Mon Nov 12 16:25:06 2007
